Set in Akihabara, the shopping area has been invaded by creatures known as "Synthisters" who prey on the patrons of Akihabara like vampires and zombies, feasting on their social energy and will to live. These enemies can only be stopped by direct exposure to sunlight, meaning that the player is required to defeat these vampires and zombies by violently stripping off their clothes and exposing them to sunlight. The storyline revolves around a conspiracy behind the Magaimono organization that the player explores. Within the game, there will be over 130 real life Akihabara shops that the player is able to visit